Cardiovascular Actions of Sodium Nitroprusside in Animals and Hypertensive Patients

Cardiovascular actions of sodium nitroprusside in animals and hypertensive patients.

Certain chemical and pharmacological properties of sodium nitroprusside, a cheap, readily available chemical, have been described. It is a powerful hypotensive agent when given intravenously to hypertensive patients. It is no more effective than the sodium thiocyanate into which it is converted when given by mouth. Prolonged infusion has proved highly effective in the treatment of hypertensive ...

Cardiovascular actions of trimetaphan nitroprusside. Comparison with sodium nitroprusside in greyhounds.

Trimetaphan nitroprusside (TNP) is a new potent hypotensive agent developed to induce and maintain decreases in arterial pressure unaccompanied by resistance. This study investigated its properties and compared them with those of sodium nitroprusside (SNP) in anaesthetized greyhounds. The mean dose response to TNP was obtained by measuring haemodynamic changes in five dogs. With increasing dose...

Morphine and Angiogenesis in Hypertensive Animals

Cardiovascular Actions of Sodium

Certain chemical and pharmacological properties of sodium nitroprusside, a cheap, readily available chemical, have been described. It is a powerful hypotensive agent when given intravenously to hypertensive patients. It is no more effective than the sodium thiocyanate into which it is converted when given by mouth. Prolonged infusion has proved highly effective in the treatment of hypertensive ...

Captopril modifies the hemodynamic and neuroendocrine responses to sodium nitroprusside in hypertensive patients.

To determine if clinically effective doses of the antihypertensive agent captopril affected the neuronal release of norepinephrine or baroreflex sensitivity, changes in plasma norepinephrine concentration and heart rate were related to the changes in mean arterial pressure seen during the intravenous infusion of stepwise incremental doses of sodium nitroprusside before and during captopril trea...